Treviamet 50 plus 500mg Tablet
Treviamet 50 plus 500mg Tablet (Sitagliptin+Metformin HCl) contains two oral antihyperglycemic agents with complementary mechanism of action to improve glycemic control with type 2 diabetes. Treviamet 50 plus 500mg Tablet is an orally-active, potent, and highly selective inhibitor of the dipeptidyl peptidase 4 (DPP-4) enzymes. Chemically,Treviamet 50 plus 500mg Tablet is 7-[(3R)-3- amino – 1-oxo -4- (2,4,5-trifluorophenyl)butyl] -5,6,7,8 -tetrahydro -3-(trifluoromethyl)- 1,2,4-triazolo[4,3-a]pyrazine phosphate (1:1) monohydrate. Treviamet 50 plus 500mg Tablet molecular formula is C16H15F6N5O•H3PO4•H2O. Monitoring of renal function Treviamet 50 plus 500mg Tablet are known to be substantially excreted by the kidney.Metformi n HCl-related lactic acidosis increases with the degree of insufficiency of renal function, therefore, serum creatinine concentrations should be determined regularly. Impaired hepatic function Since impaired hepatic function has been associated with some cases of lactic acidosis, Treviamet 50 plus 500mg Tablet should generally be avoided in patients with clinical or laboratory evidence of hepatic disease.
Sitagliptin Digoxin Sitagliptin has a small effect on plasma digoxin concentrations. No dosage adjustment of digoxin is recommended. However, patients at risk of digoxin toxicity should be monitored forthiswhen Sitagliptin and digoxin are administered concomitantly.
This medicine is used for treating type 2 diabetes (condition characterized by elevated glucose levels) that is inadequately controlled by metformin, diet and exercise. It is used for treating diabetes type 2 along with metformin or a glitazone when patients respond inadequately to diet changes, exercise and either metformin or glitazine, or in combination with sulphonylureas in patients contraindicated for metformin, and for patients that do not respond adequately to sulphonylureas alone.
Side effect :
The patients administered with this medicine may experience pancreatitis (inflammation of pancreas), allergic reactions, Stevens-Jhonson Syndrome (allergic reaction), Hypoglycemia (low glucose levels), bullous pemphigoid (large fluid-filled blisters), osteoarthritis (weak bones), upper respiratory tract infections, flatulence, swelling, and influenza (flu-like symptoms).
When not use :