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Lenwin 1gm Injection
Lenwin 1gm Injection (Cephradine) is a first-generation cephalosporin antibacterial given orally and by parenteral route in the treatment of susceptible infections and in the prophylaxis of infections during surgical procedures. Chemically, Lenwin 1gm Injection is (6R,7R)-7-[(R)-2-Amino-2-(1,4-cyclohexadien-1-yl)acetamido] -3- methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. Lenwin 1gm Injection molecular formula is C16H19N3O4S.
Lenwin 1gm Injection should be used with caution in patients with known hypersensitivity to penicillins because of partial allergenicity between penicillins and the cephalosporins. – Caution should be exercised in patients with renal failure and dosage should be reduced. – False positive reaction for glucose in the urine may occur with Benedict’s or Fehling’s solution or with reagent tablets such as Clinitest following administration of Lenwin 1gm Injection.
Prolonged use with antibiotics may result in overgrowth of non susceptible microorganisms. Drug Interactions – Concomitant administration with loop diuretics may increase nephrotoxicity of cephalosporins.
Concomitant administration of probenecid raises serum concentrations of Lenwin 1gm Injection, by reducing renal clearance. For severe or chronic infection larger dose of up to 1g four times daily may be given.
Administration should be continued for a minimum of 48- 72 hours after the patient becomes asymptomatic or evidence of bacterial eradication has been obtained. For infections caused by hemolytic strains of streptococci, a minimum of 10 days treatment is recommended to guard against the risk of rheumatic fever or glomerulo-nephritis.
Lenwin 1gm Injection is used to treat the infections of respiratory and gastrointestinal tracts, skin and soft tissue, bones and joints, septicaemia (blood poisoning), endocarditis (inflammation of the heart), urinary tract infections, and for preventing infections during surgeries.
The patients administered with this medicine may experience following:
- allergic reactions
- pseudomembranous colitis (inflammation of the lining of the large intestine).
The patients with allergy to any of the medicine’s components should avoid use of this medicine. Please consult your doctor before use.