Co-Novatec Tab 20mg,12.5mg 30’s


Co-Novatec Tab 20mg,12.5mg 30’s


Out of stock


Pack Size: 3×10’s tablet

Composition: Lisinopril (20mg)
Hydrochlorothiazidee (12.5mg)

Pharmaceutical form: Tablets

Brand Name: [button link=”” color=”purple” newwindow=”yes”] MERCK MARKER PVT LTD[/button]

Availability: In stock

Availability: Out of stock


Co-Novatec Tab 20mg,12.5mg 30’s

Co-Novatec Tab 20mg,12.5mg 30’s is a prototype drug of thiazide diuretics. Hydrochlorothiazide is antihypertensive agent. It increases the urination and reduces the amount of water and sodium retained by the body. The drugs in this class are formally called benzothiadiazide, usually shortened to thiazides. The nature of the hetrocyclic rings and the substitution on these ring may vary among the congeners but all of them retain a unsubstituted sulfonamide group. Development of thiazides and other modern diuretics began when a perceptive physician noticed that patients receiving sulfanilamide, an early antimicrobial agent, developed metabolic acidosis and a very alkaline urine. Careful study revealed that the drug was causing sodium bicarbonate diuresis. The realization that it could be useful diuretic led first to the development of acetazolamide and then to the thiazides.

. It is of Synthetic origin and belongs to Thiazide. It belongs to NaCl cotransport inhibitor pharmacological group on the basis of mechanism of action and also classified in Antihypertensive Agent, Combination pharmacological group.The Molecular Weight of Hydrochlorothiazide is 297.70. Its pKa is 7.9, 9.2.

Hydrochlorothiazide is primarily indicated in conditions like Diabetes insipidus, Edema, Hypercalciuria, Hypertension, Nephrolithiasis, Nephrotic syndrome, Oedema, Proximal renal tubular acidosis, and can also be given in adjunctive therapy as an alternative drug of choice in Exercise induced hyperkalemia, Osteoporosis, Renal hypophosphatemic rickets.


This medicine is used to treat essential or renovascular hypertension (high blood pressure due to kidney disorder).

This medication is used for lowering blood pressure in hypertensive (increased blood pressure) patients and for treating edema (excess fluid in the body) associated with heart disease. It can also be used to treat Nephrotic Syndrome.

Side Effects

  • Anorexia (weight loss)
  • abdominal discomfort

The use of this medicine is associated with side effects such as kidney failure, hypotension (low blood pressure), rash and dizziness.

When Not To Use

This medicine is not recommended to be used in patients with aortic stenosis (narrowing of aortic valve) and outflow obstruction (a type of blockage).

Patients with kidney disease must be cautious.


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