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Zurig40mg Tablet (Febuxostat) is a non-purine selective inhibitor of xanthine oxidase. Zurig 40mg Tabletis chemically described as 2-[3-cyano-4-(2-methylpropoxy) phenyl]-4-methylthiazole5-carboxylic acid. Zurig 40mg Tablet molecular formula is C16H16N2O3S. Zurig 40mg Tablet (Febuxostat) is indicated for the chronic management of hyperuricemia in patients with gout. Treatment withZurig 40mg Tablet in patients with ischemic heart disease or congestive heart failure is not recommended. − After initiation of Zurig 40mg Tablet, an increase in gout flares is frequently observed. This increase is due to reduction in serum uric acid levels resulting in mobilization of urate from tissue deposits. In order to prevent gout flares when Zurig 40mg Tablet is initiated, concurrent prophylactic treatment with an NSAID or colchicine is recommended. Zurig 40mg Tablet is contraindicated in patients with: − Hypersensitivity to the active substance or to any of the excipients of the Zurig 40mg Tablet . − Being treated with azathioprine, mercaptopurine or theophylline. − Asymptomatic hyperuricemia
Naproxen and other inhibitors of glucuronidation: Zurig 40mg Tablet metabolism depends on UGT enzymes. Medicinal products that inhibit glucuronidation, such as NSAIDs and probenecid, could in theory affect the elimination of febuxostat. In healthy subjects concomitant use of febuxostat and naproxen 250mg BID was associated with an increase in febuxostat exposure. Febuxostat can be co-administered with naproxen with no dose adjustment of febuxostat or naproxen being necessary. Patients with an overdose should be managed by symptomatic and supportive care.
Zurig 40mg Tablet (Febuxostat) is indicated for the chronic management of hyperuricemia in patients with gout .
Side effect :
Common side effects of Zurig 40mg Tablet
- Increased liver enzymes
- Skin rash
- Gout flares
When not use :
Zurig 40mg Tablet is contraindicated in patients with: − Hypersensitivity to the active substance or to any of the excipients of the product. − Being treated with azathioprine, mercaptopurine or theophylline. − Asymptomatic hyperuricemia