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Solifen 10mg Tablet
Solifen 10mg Tablet (Solifenacin Succinate) is a muscarinic receptor antagonist. Chemically, Solifen 10mg Tablet is butanedioic acid, compounded with (1S)-(3R)-1- azabicyclo[2.2.2] oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate (1:1) having molecular formula of C23H26N2O2 .C4H6O4. Pharmacological Interactions Concomitant administration with other drugs having anticholinergic properties may result in more pronounced therapeutic and side effects. An interval of approximately one week should be allowed after stopping the treatment with Solifen 10mg Tablet before commencing other cholinergic therapy. The therapeutic effect of Solifenacin Succinate may be reduced by concomitant administration of cholinergic receptor agonists. Solifen 10mg Tablet can reduce the effect of the drugs that stimulate the motility of gastrointestinal tract, such as metoclopramide and cisapride.
Angioedema of the face, lips, tongue, and/or larynx may occur after the first dose. Angioedema associated with upper airway swelling may be life threatening. If involvement of the tongue, hypopharynx, or larynx occurs, solifenacin should be promptly discontinued and appropriate therapy and/or measures necessary to ensure a patent airway should be promptly provided. Other causes of frequent urination (heart failure or renal disease) should be assessed before treatment with Solifenacin Succinate. If urinary tract infection is present, an appropriate antibacterial therapy should be started. Solifenacin Succinate should be used with caution in patients with: – clinically significant bladder outflow obstruction at risk of urinary retention. – gastrointestinal obstructive disorders
Solifen 10mg Tablet (Solifenacin Succinate) is indicated for the symptomatic treatment of urge incontinence and/or increased urinary frequency and urgency as may occur in patients with overactive bladder syndrome
Side effect :
Dry mouth. Common Constipation, nausea, dyspepsia, abdominal pain, blurred vision. Uncommon Gastroesophageal reflux diseases, dry throat, urinary tract infection, cystitis, somnolence, dysgeusia, dry eyes, fatigue, peripheral edema, nasal dryness, dry skin, difficulty in micturation.
When not use :
Solifenacin Succinate is contraindicated in patients with: – Hypersensitivity to the active substance or to any of the excipients. – Urinary retention. – Gastric retention. – Uncontrolled narrow-angle glaucoma.