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Nexum 20mg Capsule
Nexum 20mg Capsule are an enteric-coated pellet formulation of esomeprazole magnesium due to its acid labile nature. Nexum 20mg Capsule is the S-isomer of omeprazole, which is mixture of the S- and R- isomers which inhibits gastric acid secretion more effectively than omeprazole. Chemically Nexum 20mg Capsule is bis(5-methoxy-2-[(S)-[(4-methoxy-3, 5-dimethyl-2-pyridinyl)methyl]sulfinyl]- 1H-benzimidazole-1-yl) magnesium trihydrate. The molecular formula of Nexum 20mg Capsule is (C17H18N3O3S)2Mg x 3H2 O. Nexum 20mg Capsule is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid. General – Symptomatic response to therapy with Nexum 20mg Capsule does not preclude the presence of gastric malignancy. – Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated long-term with omeprazole, of which esomeprazole is an enantiomer. – Proton pump Inhibitor may be associated with an increased risk of Clostridium difficile associated diarrhea, especially in hospitalized patients. – Proton pump inhibitor (PPI) therapy may be associated with an increased risk for osteoporosis-related fractures of the hip, wrist, or spine. Patients should use the lowest dose and shortest duration of PPI therapy appropriate to the condition being treated.
Co-administration of atazanavir with proton pump inhibitors is expected to substantially decrease atazanavir plasma concentrations and may result in a loss of therapeutic effect and the development of drug resistance. – Co-administration of saquinavir with proton pump inhibitors is expected to increase saquinavir concentrations, which may increase toxicity and require dose reduction.
Nexum 20mg Capsule is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome. Esomeprazole is also used to promote healing of erosive esophagitis
Nexum 20mg Capsule can cause headache, flatulance, dry mouth, abdominal pain, diarrhea etc.
When not use
Hypersensitivity to Nexum 20mg Capsule or other proton pump inhibitors (PPIs