LIPIGET 20MG TABLET

Description

LIPIGET 20MG TABLET

LIPIGET 20MG TABLET (Atorvastatin) is a synthetic lipid-lowering agent. Atorvastatin is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in cholesterol biosynthesis. Chemically, LIPIGET 20MG TABLET is [R-(R*, R*)]-2-(4-fluorophenyl)-ß, δ-dihydroxy5- (1-methylethyl)-3-phenyl-4[(phenylamino)carbonyl]-1H-pyrrole-1 heptanoic acid, calcium salt (2:1) trihydrate. The molecular formula is (C33H34 FN2O5)2Ca•3H2O. LIPIGET 20MG TABLET (Atorvastatin) is a selective, competitive inhibitor of HMG-CoA reductase, the rate limiting enzyme responsible for the conversion of 3-hydroxy-3-methyl-glutaryl-coenzyme A to mevalonate, a precursor of sterols including cholesterol. General Before instituting therapy with atorvastatin, an attempt should be made to control hypercholesterolemia with appropriate diet, exercise, and weight reduction in obese patients, and to treat other underlying medical problems. Liver function abnormalities Liver function tests should be performed before the initiation of treatment and periodically thereafter. Patients who develop any signs or symptoms suggestive of liver injury should have liver function tests performed. Patients who develop increased transaminase levels should be monitored until the abnormality (ies) resolve. Should an increase in ALT or AST of greater than 3 times the upper limit of normal persist, reduction of dose or withdrawal of atorvastatin is recommended.

Uses

This medicine is used as an adjunct to diet in hypercholesterolemia (high cholesterol), heterozygous (genetic disorder characterized with markedly increased LDL and cholesterol )and homozygous familial hypercholesterolemia (a condition in which it is difficult to remove bad cholesterol from body), mixed hyperlipidemia (genetic disorder characterized with high lipids (fats), cholesterol and free fatty acids in blood).

 Side effects

Lipiget can cause GI upset, myalgia (muscle pain), arthralgia (pain in joints), headache, asthenia (abnormal weakness), insomnia (difficulty in sleeping), dizziness, paraesthesia (abnormal sensation of skin such as tingling, burning, chilling and numbness), hypoaesthesia , chest and back pain.

 When not use

This medicine is contraindicated in active liver disease, persistent raised liver enzymes. Adequate contraception should be ensured.