The severe or irreversible adverse effects of Artemether, which give rise to further complications include Retinopathy, Neurotoxicity, QT prolongation.Artemether produces potentially life-threatening effects which include Cardiovascular depression, Cardiopulmonary arrest. which are responsible for the discontinuation of Artemether therapy.

The signs and symptoms that are produced after the acute overdosage of Artemether include Vomiting, Convulsions, Coma, Cardiopulmonary arrest.The symptomatic adverse reactions produced by Artemether are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Anorexia, Diarrhea, Fever, Insomnia, Tinnitus, Abdominal pain, Sleep disturbancesX, Rashes, Urticaria, Pruritus, Itching, Sleep disturbance, Hypotension, Elevation of liver enzymes, Transient low fever, Abnormal gait, parasthesia, Decreased hearing.